Is Calcium Safe with Prednisolone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Ensure daily calcium intake of 1000–1500 mg through diet and supplementation. Take supplements in divided doses to maximize absorption.
Why this interaction occurs
Prednisolone decreases intestinal calcium transport proteins and increases urinary calcium loss, both contributing to negative calcium balance and osteoporosis with long-term use.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 197,017 reports mentioning Prednisolone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Prednisolone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Prednisolone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.