Is Magnesium Safe with Prednisolone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing with 200–400 mg of magnesium (glycinate or citrate form preferred) daily. Eat magnesium-rich foods such as nuts, seeds, and leafy greens. Monitor for signs of deficiency such as muscle cramps or fatigue.
Why this interaction occurs
Prednisolone increases renal magnesium excretion and alters magnesium distribution, contributing to hypomagnesemia. Low magnesium further impairs vitamin D activation and calcium regulation, compounding musculoskeletal risks associated with corticosteroid use.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 197,017 reports mentioning Prednisolone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Prednisolone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Prednisolone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.