Is CLA (Conjugated Linoleic Acid) Safe with Insulin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid CLA supplementation without close monitoring of blood glucose if you are insulin-dependent. Inform your diabetes care team before use.
Why this interaction occurs
CLA (trans-10, cis-12 isomer) has demonstrated ability to worsen insulin resistance and hyperinsulinemia in clinical trials, potentially undermining insulin therapy and destabilizing glycemic control.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 146,861 reports mentioning Insulin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Insulin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CLA (Conjugated Linoleic Acid) interactions → · All Insulin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.