Is CLA (Conjugated Linoleic Acid) Safe with Metformin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood glucose levels regularly if taking CLA alongside diabetes medications. Discuss use with your endocrinologist or prescriber before starting CLA.
Why this interaction occurs
CLA, particularly the trans-10, cis-12 isomer, has been shown in clinical studies to impair insulin sensitivity and glucose tolerance, potentially counteracting the glucose-lowering effects of metformin.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 432,898 reports mentioning Metformin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Metformin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CLA (Conjugated Linoleic Acid) interactions → · All Metformin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.