Is CoQ10 Safe with Olanzapine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
CoQ10 supplementation (100–300 mg/day) is generally considered safe with olanzapine. Inform your doctor before starting. Monitor blood glucose and lipid levels regularly, as olanzapine independently affects metabolic parameters.
Why this interaction occurs
Olanzapine is associated with mitochondrial dysfunction, oxidative stress, and metabolic disturbances including weight gain, dyslipidemia, and insulin resistance. CoQ10 is an essential mitochondrial electron transport chain cofactor with antioxidant properties. Preliminary research and mechanistic data suggest CoQ10 may partially offset olanzapine-induced oxidative damage and metabolic impairment, though large clinical trials are lacking. The interaction is potentially beneficial but not fully characterized.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 71,098 reports mentioning Olanzapine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Olanzapine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 interactions → · All Olanzapine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.