Is CoQ10 (Ubiquinone) Safe with Atorvastatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing with CoQ10 100–200 mg/day if experiencing muscle fatigue, weakness, or myalgia while on atorvastatin. Discuss with your pharmacist or physician before starting.
Why this interaction occurs
Statins inhibit HMG-CoA reductase, which also blocks the mevalonate pathway used to synthesize CoQ10 (ubiquinone). This leads to measurable reductions in plasma and muscle CoQ10 levels, potentially contributing to statin-associated muscle symptoms (SAMS) including myalgia and fatigue.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 343,939 reports mentioning Atorvastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Atorvastatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 (Ubiquinone) interactions → · All Atorvastatin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.