Is Curcumin Safe with Apixaban (Eliquis)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid curcumin supplements while taking apixaban. Seek immediate medical attention if you experience unusual bleeding, blood in urine or stool, or prolonged bleeding from cuts.
Why this interaction occurs
Curcumin inhibits P-glycoprotein (P-gp) and CYP3A4, both critical for apixaban transport and metabolism. Inhibition can significantly increase apixaban plasma concentrations. Combined with curcumin's independent antiplatelet activity, the risk of serious hemorrhage is substantially elevated.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 276,403 reports mentioning Apixaban (Eliquis). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Apixaban (Eliquis) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Curcumin interactions → · All Apixaban (Eliquis) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.