Is Curcumin Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid high-dose curcumin supplements while on warfarin. Dietary turmeric in normal food amounts is generally acceptable. Report any unusual bruising or bleeding to your provider immediately.
Why this interaction occurs
Curcumin inhibits platelet aggregation and modulates thromboxane/prostacyclin balance. It also inhibits CYP2C9 and may downregulate P-glycoprotein, increasing warfarin bioavailability. Multiple case reports document significant INR elevation with curcumin co-administration.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Curcumin interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.