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Is Curcumin Safe with Valproate?

⚠️ HIGH SEVERITY
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Valproate Curcumin
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Curcumin with Valproate — Curcumin blocks the liver enzyme (CYP2C9) that processes Valproate, potentially raising Valproate levels to toxic range. Consult your doctor or pharmacist.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 34,884 reports mentioning Valproate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Valproate + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Curcumin with Valproate?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Curcumin with Valproate — Curcumin blocks the liver enzyme (CYP2C9) that processes Valproate, potentially raising Valproate levels to toxic range. Consult your doctor or pharmacist.

Related interactions

Folate and Valproate Vitamin D and Valproate Vitamin B12 and Valproate Biotin and Valproate St. John's Wort and Valproate Milk Thistle and Valproate Ginkgo Biloba and Valproate

All Curcumin interactions →  ·  All Valproate interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.