Is Vitamin D Safe with Valproate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take vitamin D3 supplementation (1000–2000 IU/day or as prescribed). Have bone mineral density and 25-OH vitamin D levels checked regularly, especially with long-term use.
Why this interaction occurs
Valproate induces CYP24A1, which accelerates the catabolism of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, leading to hypovitaminosis D, secondary hyperparathyroidism, decreased calcium absorption, and increased risk of osteopenia and fractures.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 34,884 reports mentioning Valproate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Valproate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Valproate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.