Is DHEA Safe with Letrozole (Femara)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid concurrent use without specialist supervision. DHEA supplementation may directly counteract letrozole's aromatase inhibition, reducing treatment efficacy. Discuss with your fertility specialist before use.
Why this interaction occurs
Letrozole works by inhibiting aromatase to lower estrogen and stimulate FSH release. DHEA is a precursor to androgens and estrogens; supplementation increases substrate load for aromatase, potentially undermining letrozole's mechanism and altering ovarian stimulation response.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 63,142 reports mentioning Letrozole (Femara). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Letrozole (Femara) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All DHEA interactions → · All Letrozole (Femara) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.