Is DHEA Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining DHEA with warfarin. If use is necessary, monitor INR closely and frequently, especially when starting or stopping DHEA. Report any unusual bruising or bleeding to your provider immediately.
Why this interaction occurs
DHEA can influence hepatic cytochrome P450 enzyme activity (particularly CYP3A4) and may alter estrogen/androgen levels, which can affect warfarin metabolism and protein binding, potentially increasing bleeding risk or reducing anticoagulant efficacy unpredictably.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All DHEA interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.