Is Fat-soluble vitamins (A, D, E, K) Safe with Diatomaceous Earth?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate fat-soluble vitamin supplements (A, D, E, K) from diatomaceous earth by at least 4 hours. Consider monitoring serum vitamin D and vitamin K status with chronic concurrent use.
Why this interaction occurs
The siliceous, porous structure of diatomaceous earth can adsorb lipophilic compounds including fat-soluble vitamins within the GI tract. This physical adsorption may reduce the fraction of vitamins available for micellar incorporation and enterocyte uptake.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 90,647 reports mentioning Diatomaceous Earth. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Diatomaceous Earth + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fat-soluble vitamins (A, D, E, K) interactions → · All Diatomaceous Earth interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.