Is Vitamin B12 (oral supplements) Safe with Diatomaceous Earth?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take food-grade diatomaceous earth at the same time as vitamin B12 supplements. Separate by at least 4 hours or monitor serum B12 levels regularly.
Why this interaction occurs
Diatomaceous earth is a highly porous silica-based adsorbent. Its large surface area allows non-selective adsorption of vitamins and nutrients including B12 in the GI lumen, reducing their bioavailability before absorption can occur.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 90,647 reports mentioning Diatomaceous Earth. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Diatomaceous Earth + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin B12 (oral supplements) interactions → · All Diatomaceous Earth interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.