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Is Goldenseal Safe with Edoxaban?

⚠️ HIGH SEVERITY
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Edoxaban Goldenseal
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Goldenseal with Edoxaban — Goldenseal blocks the liver enzyme (CYP3A4) that processes Edoxaban, potentially raising Edoxaban levels to toxic range. Consult your doctor or pharmacist.

Why this interaction occurs

Berberine and hydrastine inhibit CYP3A4. Result: increased drug levels. May increase drug toxicity

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 11,507 reports mentioning Edoxaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Edoxaban + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Goldenseal with Edoxaban?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Goldenseal with Edoxaban — Goldenseal blocks the liver enzyme (CYP3A4) that processes Edoxaban, potentially raising Edoxaban levels to toxic range. Consult your doctor or pharmacist.

Related interactions

Vitamin E and Edoxaban St. John's Wort and Edoxaban Grapefruit and Edoxaban Berberine and Edoxaban Milk Thistle and Edoxaban Curcumin and Edoxaban Echinacea and Edoxaban Ginkgo Biloba and Edoxaban

All Goldenseal interactions →  ·  All Edoxaban interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.