Check my stack

Is Goldenseal Safe with Imatinib?

⚠️ HIGH SEVERITY
CHECK MY STACK
Imatinib Goldenseal
Check these in my full stack →

Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Goldenseal with Imatinib — Goldenseal blocks the liver enzyme (CYP3A4) that processes Imatinib, potentially raising Imatinib levels to toxic range. Consult your doctor or pharmacist.

Why this interaction occurs

Berberine and hydrastine inhibit CYP3A4. Result: increased drug levels. May increase drug toxicity

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 21,660 reports mentioning Imatinib. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Imatinib + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Goldenseal with Imatinib?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Goldenseal with Imatinib — Goldenseal blocks the liver enzyme (CYP3A4) that processes Imatinib, potentially raising Imatinib levels to toxic range. Consult your doctor or pharmacist.

Related interactions

Quercetin and Imatinib St. John's Wort and Imatinib Grapefruit and Imatinib Berberine and Imatinib Milk Thistle and Imatinib Curcumin and Imatinib Echinacea and Imatinib Ginkgo Biloba and Imatinib

All Goldenseal interactions →  ·  All Imatinib interactions →

Already checked this one — check your whole list

Check My Full Stack → Generate Visit Packet →
Powered by Elthio Health · elthio.health
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.