Is Quercetin Safe with Imatinib?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consult your oncologist before using quercetin supplements during imatinib therapy. Do not self-adjust imatinib dosing. Report any new side effects or symptoms of disease progression.
Why this interaction occurs
Quercetin inhibits ABCB1 (P-gp) and ABCG2 efflux transporters involved in imatinib distribution. While this may increase intracellular imatinib concentrations with potential therapeutic benefit, it can also increase systemic exposure and toxicity risk. Quercetin also independently affects CML cell signaling pathways, creating unpredictable pharmacodynamic interactions.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 21,660 reports mentioning Imatinib. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Imatinib + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Quercetin interactions → · All Imatinib interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.