Is Goldenseal Safe with Nortriptyline?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Goldenseal with Nortriptyline — Goldenseal blocks the liver enzyme (CYP2D6) that processes Nortriptyline, potentially raising Nortriptyline levels to toxic range. Consult your doctor or pharmacist.
Why this interaction occurs
Hydrastine is a potent CYP2D6 inhibitor. Result: increased drug levels. Significant interaction with opioids and antidepressants
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 22,579 reports mentioning Nortriptyline. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Nortriptyline + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Goldenseal interactions → · All Nortriptyline interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.