Is Gotu Kola Safe with Diazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution when combining. Avoid driving or hazardous activities. Discuss supplement use with your doctor, especially in elderly patients.
Why this interaction occurs
Gotu Kola (Centella asiatica) has demonstrated anxiolytic and sedative properties through modulation of GABA pathways and reduction of startle responses. Combination with benzodiazepines may enhance CNS depression beyond intended therapeutic levels.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 91,929 reports mentioning Diazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Diazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Gotu Kola interactions → · All Diazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.