Is Grapefruit Safe with Tadalafil?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Grapefruit with Tadalafil — Grapefruit blocks the liver enzyme (CYP3A4) that processes Tadalafil, potentially raising Tadalafil levels to toxic range. Consult your doctor or pharmacist.
Why this interaction occurs
Furanocoumarins irreversibly inhibit intestinal CYP3A4. Result: increased drug levels. Can increase drug levels 2-5x — dangerous with many drugs
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 34,193 reports mentioning Tadalafil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tadalafil + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit interactions → · All Tadalafil interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.