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Is Milk Thistle Safe with Tadalafil?

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Tadalafil Milk Thistle
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Use caution combining Milk Thistle with Tadalafil. Milk Thistle may mildly slow Tadalafil metabolism via CYP3A4. Monitor for increased side effects.

Why this interaction occurs

Silymarin weak CYP3A4 inhibition. Result: minimal drug level change. Generally low clinical risk

Evidence

Evidence level: limited.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 34,193 reports mentioning Tadalafil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tadalafil + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Milk Thistle with Tadalafil?
Generally yes, with awareness that Use caution combining Milk Thistle with Tadalafil. Milk Thistle may mildly slow Tadalafil metabolism via CYP3A4. Monitor for increased side effects.

Related interactions

St. John's Wort and Tadalafil Grapefruit and Tadalafil Goldenseal and Tadalafil Berberine and Tadalafil Curcumin and Tadalafil Echinacea and Tadalafil Ginkgo Biloba and Tadalafil Garlic Extract and Tadalafil

All Milk Thistle interactions →  ·  All Tadalafil interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.