Is Kava Safe with Amlodipine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Kava with Amlodipine — Kava blocks the liver enzyme (CYP3A4) that processes Amlodipine, potentially raising Amlodipine levels to toxic range. Consult your doctor or pharmacist.
Why this interaction occurs
Kavalactones inhibit CYP3A4 activity. Result: increased drug levels. May increase sedative drug levels significantly
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 372,676 reports mentioning Amlodipine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Amlodipine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Kava interactions → · All Amlodipine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.