Is Magnesium Safe with Amlodipine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
If taking magnesium supplements, inform your doctor. Monitor blood pressure regularly. Avoid high-dose magnesium (>350 mg/day supplemental) without medical supervision as it may enhance the hypotensive effect.
Why this interaction occurs
Magnesium acts as a natural calcium antagonist by competing with calcium at voltage-gated channels. Combined use with calcium channel blockers like amlodipine can produce additive vasodilatory and hypotensive effects, increasing risk of symptomatic hypotension.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 372,676 reports mentioning Amlodipine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Amlodipine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Amlodipine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.