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Is Kava Safe with Chlorzoxazone?

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Chlorzoxazone Kava
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Kava with Chlorzoxazone — Kava blocks the liver enzyme (CYP2E1) that processes Chlorzoxazone, potentially raising Chlorzoxazone levels to toxic range. Consult your doctor or pharmacist.

Why this interaction occurs

Kava significantly inhibits CYP2E1 — liver toxicity risk. Result: increased drug toxicity.

Evidence

Evidence level: strong.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 1,473 reports mentioning Chlorzoxazone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Chlorzoxazone + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Kava with Chlorzoxazone?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Kava with Chlorzoxazone — Kava blocks the liver enzyme (CYP2E1) that processes Chlorzoxazone, potentially raising Chlorzoxazone levels to toxic range. Consult your doctor or pharmacist.

Related interactions

Garlic Extract and Chlorzoxazone Kava and Tramadol Kava and Oxycodone Kava and Hydrocodone Kava and Codeine Kava and Zolpidem Kava and Eszopiclone Kava and Temazepam

All Kava interactions →  ·  All Chlorzoxazone interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.