Is Kava Safe with Temazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
NEVER combine kava with temazepam. This combination can cause life-threatening respiratory depression. If accidental ingestion occurs, call emergency services (911) immediately.
Why this interaction occurs
Temazepam, a benzodiazepine, and kava both act on GABA-A receptors, producing profound additive CNS depression. Kava's CYP enzyme inhibition may also increase temazepam bioavailability. Case reports associate kava-benzodiazepine combinations with coma and ICU-level sedation.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 31,453 reports mentioning Temazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Temazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Kava interactions → · All Temazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.