Is Valerian Safe with Temazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take valerian with temazepam. Their combined GABAergic effects significantly increase drowsiness, fall risk, and respiratory depression risk, particularly in older adults. Report excessive sedation to your doctor immediately.
Why this interaction occurs
Valerian constituents bind GABA-A receptors in a manner similar to benzodiazepines, directly compounding temazepam's mechanism of action. This pharmacodynamic synergy increases the probability of excessive sedation, respiratory compromise, paradoxical agitation, and physical dependence reinforcement.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 31,453 reports mentioning Temazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Temazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Valerian interactions → · All Temazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.