Is Lemon Balm Safe with Lorazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining. Do not drive or operate machinery. Inform your prescriber immediately if using Lemon Balm alongside benzodiazepines.
Why this interaction occurs
Lemon Balm (Melissa officinalis) enhances GABA-A receptor activity and inhibits GABA transaminase, increasing GABAergic tone. Combined with benzodiazepines, this may cause excessive sedation, respiratory depression, and psychomotor impairment.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 139,367 reports mentioning Lorazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lorazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Lemon Balm interactions → · All Lorazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.