Is Melatonin Safe with Lorazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution if combining. Take melatonin only at bedtime and at the lowest effective dose (0.5–1 mg). Avoid driving the next morning. Discuss use with your prescriber, especially if daytime alertness is required.
Why this interaction occurs
Melatonin has intrinsic sedative and hypnotic properties mediated via MT1/MT2 receptors. When combined with lorazepam, additive CNS depression may prolong sedation and worsen next-day psychomotor impairment beyond what is expected from lorazepam alone.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 139,367 reports mentioning Lorazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lorazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Melatonin interactions → · All Lorazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.