Is Magnesium Safe with Diltiazem?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood pressure and heart rate when using magnesium supplements alongside diltiazem. Keep supplemental magnesium at or below the recommended daily allowance (310–420 mg/day from all sources) unless directed by your physician.
Why this interaction occurs
Magnesium's calcium antagonist properties can compound diltiazem's vasodilatory and negative chronotropic effects, particularly in patients with pre-existing conduction abnormalities or renal impairment where magnesium clearance may be reduced.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 73,173 reports mentioning Diltiazem. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Diltiazem + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Diltiazem interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.