Is Magnesium Safe with Ciprofloxacin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid taking magnesium supplements within 2 hours before or 6 hours after Ciprofloxacin.
Why this interaction occurs
Magnesium cations chelate with the 4-oxo and 3-carboxyl groups of ciprofloxacin, forming poorly absorbed complexes and significantly lowering systemic drug concentrations.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 86,830 reports mentioning Ciprofloxacin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ciprofloxacin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Ciprofloxacin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.