Is Psyllium Husk Safe with Ciprofloxacin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take psyllium husk within 3-4 hours of ciprofloxacin. Take ciprofloxacin on an empty stomach and delay fiber supplementation to avoid binding in the GI tract.
Why this interaction occurs
Psyllium husk forms a viscous gel in the GI tract that can physically bind ciprofloxacin, reducing its bioavailability and peak plasma concentration. This can result in subtherapeutic antibiotic levels and potential treatment failure, particularly in serious infections.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 86,830 reports mentioning Ciprofloxacin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ciprofloxacin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Psyllium Husk interactions → · All Ciprofloxacin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.