Is Magnesium Safe with Oral contraceptives?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing with 200–400 mg of magnesium glycinate or citrate daily. Adequate magnesium may also help reduce OC-associated headaches and migraines. Discuss with your provider before supplementing.
Why this interaction occurs
Estrogen in oral contraceptives promotes magnesium uptake into soft tissues and bone, reducing serum magnesium levels. Low magnesium is associated with increased menstrual migraines, muscle cramps, anxiety, insulin resistance, and cardiovascular irregularities in OC users.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 22,854 reports mentioning Oral contraceptives. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Oral contraceptives + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Oral contraceptives interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.