Is Vitamin B6 (Pyridoxine) Safe with Oral contraceptives?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing with 10–25 mg of Vitamin B6 daily. Discuss with your healthcare provider if you experience depression, irritability, or fatigue while on birth control.
Why this interaction occurs
Oral contraceptives alter tryptophan metabolism, increasing demand for B6 as a cofactor. This can lead to functional B6 deficiency, contributing to mood changes, depression, and peripheral neuropathy in some women.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 22,854 reports mentioning Oral contraceptives. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Oral contraceptives + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin B6 (Pyridoxine) interactions → · All Oral contraceptives interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.