Check my stack

Is Milk Thistle Safe with Amlodipine?

✓ LOW SEVERITY
CHECK MY STACK
Amlodipine Milk Thistle
Check these in my full stack →

Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Use caution combining Milk Thistle with Amlodipine. Milk Thistle may mildly slow Amlodipine metabolism via CYP3A4. Monitor for increased side effects.

Why this interaction occurs

Silymarin weak CYP3A4 inhibition. Result: minimal drug level change. Generally low clinical risk

Evidence

Evidence level: limited.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 372,676 reports mentioning Amlodipine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Amlodipine + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Milk Thistle with Amlodipine?
Generally yes, with awareness that Use caution combining Milk Thistle with Amlodipine. Milk Thistle may mildly slow Amlodipine metabolism via CYP3A4. Monitor for increased side effects.

Related interactions

Magnesium and Amlodipine Rhodiola and Amlodipine Hawthorn and Amlodipine DHA (Docosahexaenoic Acid) and Amlodipine Green Coffee Extract and Amlodipine Arnica and Amlodipine St. John's Wort and Amlodipine Goldenseal and Amlodipine

All Milk Thistle interactions →  ·  All Amlodipine interactions →

Already checked this one — check your whole list

Check My Full Stack → Generate Visit Packet →
Powered by Elthio Health · elthio.health
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.