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Is Milk Thistle Safe with Glibenclamide?

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Glibenclamide Milk Thistle
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Use caution combining Milk Thistle with Glibenclamide. Milk Thistle may mildly slow Glibenclamide metabolism via CYP2C9. Monitor for increased side effects.

Why this interaction occurs

Silymarin inhibits CYP2C9 in vitro — clinical significance unclear. Result: slightly increased drug levels.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 4,059 reports mentioning Glibenclamide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Glibenclamide + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Milk Thistle with Glibenclamide?
Generally yes, with awareness that Use caution combining Milk Thistle with Glibenclamide. Milk Thistle may mildly slow Glibenclamide metabolism via CYP2C9. Monitor for increased side effects.

Related interactions

St. John's Wort and Glibenclamide Curcumin and Glibenclamide Ginkgo Biloba and Glibenclamide Milk Thistle and Warfarin Milk Thistle and Tacrolimus Milk Thistle and Metformin Milk Thistle and Acenocoumarol Milk Thistle and Phenytoin

All Milk Thistle interactions →  ·  All Glibenclamide interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.