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Is Curcumin Safe with Glibenclamide?

⚠️ HIGH SEVERITY
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Glibenclamide Curcumin
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Curcumin with Glibenclamide — Curcumin blocks the liver enzyme (CYP2C9) that processes Glibenclamide, potentially raising Glibenclamide levels to toxic range. Consult your doctor or pharmacist.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 4,059 reports mentioning Glibenclamide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Glibenclamide + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Curcumin with Glibenclamide?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Curcumin with Glibenclamide — Curcumin blocks the liver enzyme (CYP2C9) that processes Glibenclamide, potentially raising Glibenclamide levels to toxic range. Consult your doctor or pharmacist.

Related interactions

St. John's Wort and Glibenclamide Milk Thistle and Glibenclamide Ginkgo Biloba and Glibenclamide Curcumin and Warfarin Curcumin and Tamoxifen Curcumin and Apixaban (Eliquis) Curcumin and Atorvastatin Curcumin and Simvastatin

All Curcumin interactions →  ·  All Glibenclamide interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.