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Is Milk Thistle Safe with Glyburide?

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Glyburide Milk Thistle
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Use caution combining Milk Thistle with Glyburide. Milk Thistle may mildly slow Glyburide metabolism via CYP2C9. Monitor for increased side effects.

Why this interaction occurs

Silymarin inhibits CYP2C9 in vitro — clinical significance unclear. Result: slightly increased drug levels.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 26,393 reports mentioning Glyburide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Glyburide + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Milk Thistle with Glyburide?
Generally yes, with awareness that Use caution combining Milk Thistle with Glyburide. Milk Thistle may mildly slow Glyburide metabolism via CYP2C9. Monitor for increased side effects.

Related interactions

St. John's Wort and Glyburide Curcumin and Glyburide Ginkgo Biloba and Glyburide Milk Thistle and Warfarin Milk Thistle and Tacrolimus Milk Thistle and Metformin Milk Thistle and Acenocoumarol Milk Thistle and Phenytoin

All Milk Thistle interactions →  ·  All Glyburide interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.