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Is Milk Thistle Safe with Sildenafil?

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Sildenafil Milk Thistle
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Use caution combining Milk Thistle with Sildenafil. Milk Thistle may mildly slow Sildenafil metabolism via CYP3A4. Monitor for increased side effects.

Why this interaction occurs

Silymarin weak CYP3A4 inhibition. Result: minimal drug level change. Generally low clinical risk

Evidence

Evidence level: limited.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 61,253 reports mentioning Sildenafil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Sildenafil + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Milk Thistle with Sildenafil?
Generally yes, with awareness that Use caution combining Milk Thistle with Sildenafil. Milk Thistle may mildly slow Sildenafil metabolism via CYP3A4. Monitor for increased side effects.

Related interactions

L-Arginine and Sildenafil St. John's Wort and Sildenafil Grapefruit and Sildenafil Goldenseal and Sildenafil Berberine and Sildenafil Curcumin and Sildenafil Echinacea and Sildenafil Ginkgo Biloba and Sildenafil

All Milk Thistle interactions →  ·  All Sildenafil interactions →

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Educational only — not medical advice.
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