Is L-Arginine Safe with Sildenafil?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution and monitor for symptomatic hypotension.
Why this interaction occurs
L-Arginine is a direct precursor to nitric oxide (NO) synthesis. Sildenafil inhibits PDE-5, prolonging NO-mediated vasodilation. The combination can produce additive hypotension through compounded NO pathway activation.
Evidence
Evidence level: strong.
Data source
Dong et al., American Heart Journal 2011; Shiraseb et al., Advances in Nutrition 2022; Xu et al., Andrologia 2021
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 61,253 reports mentioning Sildenafil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Sildenafil + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All L-Arginine interactions → · All Sildenafil interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.