Is Niacin (Vitamin B3) Safe with rosuvastatin?

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rosuvastatin Niacin (Vitamin B3)

Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Carefully consider whether the benefit of using lipid-modifying doses (≥1 g/day) of niacin together with rosuvastatin outweighs the increased risk. If used together, monitor closely for muscle pain, weakness, or tenderness, especially when starting therapy or increasing the dose of either drug.

Why this interaction occurs

Cases of myopathy and rhabdomyolysis have occurred with concomitant use of lipid-modifying dosages (≥1 g/day) of niacin with rosuvastatin tablets.

Evidence

Evidence level: strong.

Data source

FDA Drug Label

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 115,467 reports mentioning rosuvastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the rosuvastatin + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Niacin (Vitamin B3) with rosuvastatin?

Avoid unless your doctor or pharmacist directs otherwise. Carefully consider whether the benefit of using lipid-modifying doses (≥1 g/day) of niacin together with rosuvastatin outweighs the increased risk. If used together, monitor closely for muscle pain, weakness, or tenderness, especially when starting therapy or increasing the dose of either drug.

Related interactions

All Niacin (Vitamin B3) interactions → · All rosuvastatin interactions →

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