Is Niacin (Vitamin B3) Safe with atorvastatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider whether the benefit of using lipid-modifying dosages of niacin (≥1 gram/day) with atorvastatin outweighs the increased risk. If used together, monitor for signs and symptoms of myopathy, particularly during initiation and dose increases.
Why this interaction occurs
Cases of myopathy and rhabdomyolysis have been observed with concomitant use of lipid-modifying dosages of niacin (≥1 gram/day) with atorvastatin calcium.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 343,939 reports mentioning atorvastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the atorvastatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Niacin (Vitamin B3) interactions → · All atorvastatin interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.