Is Quercetin Safe with Docetaxel?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take quercetin supplements during taxane-based chemotherapy without oncologist guidance. The timing and dose of any supplement must be carefully coordinated to avoid unintended pharmacokinetic changes.
Why this interaction occurs
Docetaxel is a P-glycoprotein (ABCB1) substrate. Quercetin's well-documented P-gp inhibitory activity can increase docetaxel intestinal absorption and reduce biliary excretion, potentially elevating plasma concentrations and increasing risk of docetaxel toxicity including myelosuppression and peripheral neuropathy.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 71,023 reports mentioning Docetaxel. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Docetaxel + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Quercetin interactions → · All Docetaxel interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.