Is Red Clover Safe with Tamoxifen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Soft caution only. Keep oncology team informed.
Why this interaction occurs
Red clover isoflavones have weak phytoestrogenic activity and may theoretically compete with tamoxifen at estrogen receptor sites. However, this concern has not been demonstrated in human or rat pharmacokinetic data, and clinical significance remains uncertain.
Evidence
Evidence level: moderate.
Data source
Raju et al., Scientific Reports 2015; Ferraris et al., Breast Cancer Research and Treatment 2020; Fritz et al., PLoS One 2013; Duffy et al., CA Cancer J Clin 2007
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 22,724 reports mentioning Tamoxifen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tamoxifen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Red Clover interactions → · All Tamoxifen interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.