Is Resveratrol Safe with Tamoxifen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take resveratrol without oncologist approval during tamoxifen therapy. The potential for reduced cancer treatment efficacy makes this a clinically significant concern that must be evaluated individually.
Why this interaction occurs
Resveratrol is a phytoestrogen that binds estrogen receptors (ERα and ERβ) and can act as an estrogen receptor agonist or antagonist depending on concentration and tissue type. This competitive binding may antagonize tamoxifen's therapeutic blockade of estrogen receptors in breast cancer cells, potentially reducing treatment efficacy in ER-positive breast cancer.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 22,724 reports mentioning Tamoxifen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tamoxifen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Resveratrol interactions → · All Tamoxifen interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.