Is Riboflavin (Vitamin B2) Safe with Ethinyl estradiol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Ensure adequate riboflavin intake through diet (dairy, eggs, lean meats) or supplement with 10–25 mg of B2 daily. Riboflavin is especially important for women with migraines associated with OCP use.
Why this interaction occurs
Oral contraceptives have been shown to reduce erythrocyte glutathione reductase activity, an indicator of functional riboflavin deficiency. B2 is critical for energy metabolism, antioxidant function, and activation of other B vitamins including B6 and folate.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 240,329 reports mentioning Ethinyl estradiol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ethinyl estradiol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Riboflavin (Vitamin B2) interactions → · All Ethinyl estradiol interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.