Is Zinc Safe with Ethinyl estradiol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Ensure adequate dietary zinc intake (8 mg/day for women). If supplementing, use 15–25 mg of zinc with food to avoid nausea. Monitor for signs of deficiency such as poor wound healing, hair loss, or immune dysfunction.
Why this interaction occurs
Oral contraceptives containing estrogen can lower plasma zinc levels, possibly by redistributing zinc to tissues or altering carrier proteins. While frank deficiency is uncommon, marginal zinc status may affect immune function and skin health.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 240,329 reports mentioning Ethinyl estradiol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ethinyl estradiol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Ethinyl estradiol interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.