Is royal jelly Safe with warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take royal jelly while on warfarin. If already taking it, stop immediately and contact your doctor for an urgent INR check. Report any blood in urine, unusual bruising, or prolonged bleeding.
Why this interaction occurs
Royal jelly appears to potentiate the anticoagulant effect of warfarin, causing clinically significant INR elevation (6.88–7.29 in reported case) and bleeding complications such as hematuria. The exact pharmacokinetic or pharmacodynamic mechanism is not yet established.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 16553520
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All royal jelly interactions → · All warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.