Is Sage Extract Safe with Memantine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use with caution. Monitor for dizziness, confusion, or enhanced sedation. Inform your neurologist before starting Sage Extract.
Why this interaction occurs
Sage Extract has demonstrated NMDA receptor modulation and AChE inhibitory activity. Combined with memantine (NMDA antagonist), there may be unpredictable CNS interactions altering glutamate regulation and cognitive function.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 17,002 reports mentioning Memantine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Memantine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Sage Extract interactions → · All Memantine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.