Is Sage Extract Safe with Donepezil?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consult your physician before combining. Watch for signs of cholinergic excess such as increased sweating, GI upset, or slow heartbeat.
Why this interaction occurs
Salvia officinalis (Sage) contains rosmarinic acid and other compounds shown to inhibit acetylcholinesterase. Concurrent use with donepezil may additively elevate acetylcholine levels, risking cholinergic toxicity.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 25,232 reports mentioning Donepezil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Donepezil + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Sage Extract interactions → · All Donepezil interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.