Is SAM-e Safe with Bupropion?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use with caution. Consult your doctor before starting SAM-e. Report any symptoms of anxiety, agitation, rapid heartbeat, or mood changes promptly.
Why this interaction occurs
SAM-e (S-adenosylmethionine) has independent antidepressant properties and influences monoamine neurotransmitter synthesis including dopamine and norepinephrine. Combining with Bupropion may lead to additive CNS stimulatory effects and unpredictable mood changes.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 79,183 reports mentioning Bupropion. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Bupropion + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All SAM-e interactions → · All Bupropion interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.